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Nevertheless, no previous study has been performed by analysing the same samples that were employed in assisted reproduction. The main objective of this work was to correlate sperm chromatin dispersion SCD , measured by the SCD test, with semen parameters and pregnancy outcome in intrauterine insemination IUI. Sperm recovered by swim-up did not show a significant improvement in DNA integrity. IUI is the first line of treatment in couples where pregnancy is not achieved naturally but no severe infertility problems are found on initial investigation. This initial investigation includes a semen analysis, following the World Health Organization guidelines WHO, , hormonal determinations and the assessment of tubal patency by hysterosalpingography in the female Requena et al. There are different problems treatable by IUI, such as mild—moderate male factor, cervical factor, partial tubal permeability or ovulatory disorders Requena et al. The best IUI results are achieved when ovaries are gently stimulated to obtain two mature follicles, without an associated increase of multiple pregnancy risk Zuzuarregui et al.

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