Metastatic meningeal breast cancer

Central nervous system CNS metastasis from breast cancer may be characterized as either parenchymal brain metastasis BM or leptomeningeal LM metastasis. CNS metastasis in breast cancer has been associated with reduced overall survival, with the shortest survival generally observed in cases of LM. Here, we review the epidemiology, prognostic factors, diagnostic tools, currently available treatments, and potential future therapies for LM from breast cancer. With improved systemic therapies successfully resulting in more long-term survivors with advanced cancers, the incidence of central nervous system CNS metastasis is increasing [ 1 , 2 ].
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Leptomeningeal metastases in breast cancer

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Leptomeningeal metastases in breast cancer

Metrics details. The incidence of meningeal carcinomatosis appears to be higher than in the past due to advances in neuro-imaging diagnostic techniques and improvements in cancer survival. Among solid tumors, breast cancer is the cancer most commonly associated with meningeal carcinomatosis, with an incidence rate of between 0. Aim of this study has been i to evaluate the incidence of meningeal carcinomatosis in a continuous breast cancer unselected series treated in a dedicated Breast Unit and ii to define the clinico-pathological and molecular parameters associated with meningeal carcinomatosis development. A retrospective series of consecutive patients surgically treated for breast cancer between and was collected. Clinico-pathological data were recorded from medical charts and pathological reports, including the date of development of symptomatic meningeal carcinomatosis. Meningeal carcinomatosis incidence was determined at both 5- and year follow-ups.
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A model of breast cancer meningeal metastases: characterization with in vivo molecular imaging

We present a case of a year-old female diagnosed with invasive ductal breast cancer, which was treated and in remission for 12 years. In she presented a progressive dorsal back pain, which prevented her from performing basic tasks. An MR study was performed and revealed the presence of an extramedullary metastatic sleeve located in the thoracic intradural space. Concomitant multiple small nodular foci were adhering diffusely to the spinal cord, compatible with leptomeningeal metastatic disease. The occurrence of both forms of spread in the spine is uncommon, and its distinction on imaging is of particular importance taking into account the differences in treatment approach and prognosis.
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We will be contacting patients. Read more. Cells from some types of cancer, such as breast cancer, lung cancer, and melanoma, can sometimes spread to your meninges, cerebrospinal fluid CSF , or both.
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